Personalizing Medicine: 5-FU Dosing in Colorectal Cancer
THE CHICAGO FIREHOUSE, 1401 South Michigan Avenue, Chicago, IL 60605Jun 3rd, 6:00 PM - 7:45 PM
Edward Chu, MD
Professor of Medicine and Pharmacology & Chemical Biology
Chief, Division of Hematology-Oncology
Deputy Director, University of Pittsburgh Cancer Institute
University of Pittsburgh School of Medicine
Edward Kaplan, MD
Assistant Professor of Medicine
Rush Medical College
Rush-Presbyterian-St. Luke’s Medical Center
This activity addresses the needs of oncologists seeking further understanding about personalizing 5-FU dosing in patients with colorectal cancer.
Until recently, 5-FU dosing in patients with colorectal cancer has been based on body surface area (BSa). This one-size-fits-all approach to testing does not take into account patient-specific parameters such as renal or hepatic clearance, drug interactions, age, sex, and genetic differences, or other reasons for clearance variability, and may result in patients being regularly over- or under-dosed.
Join us as Edward Chu, MD, and Edward Kaplan, MD, review data on the correlation between plasma levels of 5-FU and the drug’s biological effect, the benefit of personalizing 5-FU dosing to eliminate toxicity and increase effectiveness of treatment, and the practical implementation of pharmacokinetic monitoring of 5-FU into your practice.
At this dinner presentation, our panel will review the following:
- The correlation between plasma levels/AUC of 5-FU and biological effect – efficacy and toxicity
- The benefit of pharmacokinetics-guided dosing of 5-FU
- The application of pharmacokinetics for dose adjustment of 5-FU in colorectal cancer for adjuvant chemotherapy or treatment of metastatic disease
At the end of this program, the oncologist will have the knowledge, strategies, and tools to better understand the benefit of personalizing 5-FU dosing in order to minimize toxicity and increase treatment effectiveness. The oncologist will be equipped with the information needed to integrate into practice how to treat the right patient with the right drug at the right dose.
After completing this activity, the participant should be better able to:
1. Explain the correlation between plasma levels/AUC of 5-FU and biological effect – efficacy and toxicity
2. Describe the benefits of pharmacokinetics-guided dosing of infusional 5-FU
3. Discuss the application of pharmacokinetic monitoring for dose adjustment of 5-FU in colorectal cancer adjuvant chemotherapy or treatment of metastatic disease
6:00 PM – 6:15 PM Registration / Dinner Served
6:15 PM – 7:30 PM Personalizing Medicine: 5-FU Dosing in Colorectal Cancer
7:30 PM – 7:45 PM Question & Answer Session
Space is limited, so reserve your seat now. RSVP by May 31, 2012.
Physician Continuing Medical Education
Physician Accreditation Statement
Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Physician Credit Designation
Global Education Group designates this live activity for a maximum of 1.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosure of Conflicts of interest
Global Education Group (Global) requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.
Americans with Disabilities Act
Event staff will be glad to assist you with any special needs (e.g., physical, dietary, etc.). Please contact Minerva Medical Communications prior to the live event at (904) 388-3265.
For more information about the accreditation of this program, please contact Global at (303) 395-1782 or email@example.com.
This activity is sponsored by Global Education Group. Logistics support is provided by Minerva Medical Communications.